PO: If order is \"'swish and swallow,\" instruct patient to hold medication in mouth for several minutes before swallowing\n\nTopical cream\/powder: apply liberally twice daily<\/td>\n
Improve symptoms of yeast infection of skin<\/td>\n
Check for allergies\n\nRoute: IV\n\nReconstitute and dilute as directed on packaging\n\nAdminister slowly over several hours initially and monitor VS every 30 minutes; may require premedication\n\nTherapy may take several months\n\nAlert: Different amphotericin B preparations aren't interchangeable\n\nCaution if renal impairment\n\nBlack Box Warning: Don't use to treat noninvasive forms of fungal disease in patients with normal neutrophil counts<\/td>\n
Improvement of systemic fungal infection such as aspergillis<\/td>\n
Monitor fluid intake and output; report change in urine appearance or volume\n\nMonitor BUN and creatinine levels two or three times weekly. Kidney damage may be reversible if drug is stopped at first sign of renal dysfunction\n\nHydrate patient before infusion to reduce risk of nephrotoxicity\n\nObtain liver function tests once or twice weekly\n\nMonitor CBC weekly\n\nMonitor potassium level closely and report signs of hypokalemia\n\nCheck calcium and magnesium levels twice weekly\n\nDrug may be ototoxic. Report evidence of hearing loss, tinnitus, vertigo, or unsteady gait<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \n
Critical Thinking Activity 3.15a<\/strong><\/h2>\nUsing the above grid information, consider the following clinical scenario question:<\/strong>\n\nA patient in a skilled nursing facility has been receiving nystatin applied to groin folds twice daily for several weeks, but there is no sign of improvement. What is the nurse's best response?\n\nNote: Answers to the Critical Thinking activities can be found in the \"Answer Key\" sections at the end of the book.","rendered":"
Figure 3.13 Candida albicans is a unicellular fungus, or yeast. It is the causative agent of vaginal yeast infections as well as oral thrush, a yeast infection of the mouth that commonly afflicts infants.<\/figcaption><\/figure>\n
Reconstitute and dilute as directed on packaging<\/p>\n
Administer slowly over several hours initially and monitor VS every 30 minutes; may require premedication<\/p>\n
Therapy may take several months<\/p>\n
Alert: Different amphotericin B preparations aren’t interchangeable<\/p>\n
Caution if renal impairment<\/p>\n
Black Box Warning: Don’t use to treat noninvasive forms of fungal disease in patients with normal neutrophil counts<\/td>\n
Improvement of systemic fungal infection such as aspergillis<\/td>\n
Monitor fluid intake and output; report change in urine appearance or volume<\/p>\n
Monitor BUN and creatinine levels two or three times weekly. Kidney damage may be reversible if drug is stopped at first sign of renal dysfunction<\/p>\n
Hydrate patient before infusion to reduce risk of nephrotoxicity<\/p>\n
Obtain liver function tests once or twice weekly<\/p>\n
Monitor CBC weekly<\/p>\n
Monitor potassium level closely and report signs of hypokalemia<\/p>\n
Check calcium and magnesium levels twice weekly<\/p>\n
Drug may be ototoxic. Report evidence of hearing loss, tinnitus, vertigo, or unsteady gait<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
Using the above grid information, consider the following clinical scenario question:<\/strong><\/p>\n
A patient in a skilled nursing facility has been receiving nystatin applied to groin folds twice daily for several weeks, but there is no sign of improvement. What is the nurse’s best response?<\/p>\n
Note: Answers to the Critical Thinking activities can be found in the “Answer Key” sections at the end of the book.<\/p>\n
![\"Photomicrograph](\"https:\/\/pressbooks.publishdot.com\/nursingpharmacology\/wp-content\/uploads\/sites\/5\/2019\/09\/image14.png\" "\\"This")
Figure 3.13 Candida albicans is a unicellular fungus, or yeast. It is the causative agent of vaginal yeast infections as well as oral thrush, a yeast infection of the mouth that commonly afflicts infants.[\/caption]\n\n[footnote]This image is a derivative of \"Candida albicans\" by Dr. Gordon Roberstad, <\/span>Centers of Disease Control and Prevention<\/a>. \u00a0<\/span>https:\/\/cnx.org\/contents\/y54zcuVm@1\/Characteristics-of-Fungi<\/a>, licensed under <\/span>CC0<\/a>[\/footnote]<\/sup>\n\nFungi are important to humans in a variety of ways. Both microscopic and macroscopic fungi have medical relevance, but some pathogenic species that can cause mycoses<\/strong> (illnesses caused by fungi). See Figure 3.13 for a microscopic image of candida albicans that is the causative agent of yeast infections. Some pathogenic fungi are opportunistic, meaning that they mainly cause infections when the host's immune defenses are compromised and do not normally cause illness in healthy individuals. Fungi are important in other ways. They act as decomposers in the environment, and they are critical for the production of certain foods such as cheeses. Fungi are also major sources of antibiotics, such as penicillin from the fungus Penicillium<\/em>.[footnote]This work is a derivative of Microbiology<\/a> by OpenStax<\/a> licensed under CC BY 4.0<\/a>. Access for free at https:\/\/openstax.org\/books\/microbiology\/pages\/1-introduction<\/a>[\/footnote]. <\/sup>\n\nIndications:<\/strong>\n\nImidazoles<\/strong> are synthetic fungicides commonly used in medical applications and also in agriculture to keep seeds and harvested crops from molding. Examples include miconazole, ketoconazole, and clotrimazole, which are used to treat fungal skin infections such as ringworm, specifically tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea corporis.\n\nTriazole<\/strong> drugs, including fluconazole, can be administered orally or intravenously for the treatment of several types of systemic yeast infections, including oral thrush and cryptococcal meningitis, both of which are prevalent in patients with AIDS. Triazoles also exhibit more selective toxicity, compared with the imidazoles, and are associated with fewer side effects.[footnote]This work is a derivative of Microbiology<\/a> by OpenStax<\/a> licensed under CC BY 4.0<\/a>. Access for free at https:\/\/openstax.org\/books\/microbiology\/pages\/1-introduction<\/a>[\/footnote]<\/sup>\n\nAllylamines<\/strong>, a structurally different class of synthetic antifungal drugs, are most commonly used topically for the treatment of dermatophytic skin infections like athlete's foot, ringworm, and jock itch. Oral treatment with terbinafine is also used for fingernail and toenail fungus, but it can be associated with the rare side effect of hepatotoxicity.[footnote]This work is a derivative of Microbiology<\/a> by OpenStax<\/a> licensed under CC BY 4.0<\/a>. Access for free at https:\/\/openstax.org\/books\/microbiology\/pages\/1-introduction<\/a>[\/footnote]<\/sup>\n\nPolyenes<\/strong> are a class of antifungal agents naturally produced by certain actinomycete soil bacteria and are structurally related to macrolides. Common examples include nystatin and amphotericin B. Nystatin is typically used as a topical treatment for yeast infections of the skin, mouth, and vagina, but may also be used for intestinal fungal infections. The drug amphotericin B is used for systemic fungal infections like aspergillosis, cryptococcal meningitis, histoplasmosis, blastomycosis, and candidiasis. Amphotericin B was the only antifungal drug available for several decades, but its use has associated serious side effects, including nephrotoxicity.[footnote]This work is a derivative of Microbiology<\/a> by OpenStax<\/a> licensed under CC BY 4.0<\/a>. Access for free at https:\/\/openstax.org\/books\/microbiology\/pages\/1-introduction<\/a>[\/footnote]<\/sup>\n\nMechanism of Action:<\/strong> Antifungals disrupt ergosterol biosyntheses of the cell membrane increasing cellular permeability and causing cell death.\n\nSpecial Administration Considerations:<\/strong> Administration guidelines will vary depending on the type of fungal infection being treated. It is important to monitor response of the affected area and examine class specific administration considerations to monitor patient response.\n\nPatient Teaching & Education: <\/strong>The patient should be advised to follow dosage instructions carefully and finish the drug completely, even if they feel their symptoms have resolved.\u00a0 The patient should report any skin rash, abdominal pain, fever, or diarrhea to the provider.\u00a0 The patient should monitor carefully for unexplained bruising or bleeding, which may be a sign of liver dysfunction.[footnote]uCentral from Unbound Medicine. https:\/\/www.unboundmedicine.com\/ucentral<\/a>[\/footnote]<\/sup>\n\nNow let's take a closer look at the medication grid for various antifungals in Table 3.15.[footnote]Daily Med, https:\/\/dailymed.nlm.nih.gov\/dailymed\/index.cfm<\/a>, used for hyperlinked medications in this module. Retrieved June 27, 2019[\/footnote]<\/sup>\n\nTable 3.15 Antifungal Medication Grid\n