{"id":400,"date":"2019-11-15T19:10:33","date_gmt":"2019-11-15T19:10:33","guid":{"rendered":"https:\/\/pressbooks.publishdot.com\/nursingpharmacology\/chapter\/9-2-endocrine-system-basics\/"},"modified":"2021-12-07T11:28:30","modified_gmt":"2021-12-07T11:28:30","slug":"9-2-endocrine-system-basics","status":"publish","type":"chapter","link":"https:\/\/pressbooks.publishdot.com\/nursingpharmacology\/chapter\/9-2-endocrine-system-basics\/","title":{"raw":"9.2 Endocrine System Basics","rendered":"9.2 Endocrine System Basics"},"content":{"raw":"
\n\nYou may never have thought of it this way, but when you send a text message to two friends to meet you at a restaurant at six, you're sending digital signals that you hope will affect their behavior\u2014even though they are some distance away. Similarly, certain cells send chemical signals to other cells in the body that influence their behavior. This long-distance intercellular communication, coordination, and control are critical for homeostasis, and it is the fundamental function of the endocrine system.\n\nWhereas the nervous system uses neurotransmitters to communicate, the endocrine system uses [pb_glossary id=\"1795\"]hormones[\/pb_glossary]<\/strong> for chemical signaling. These hormone signals are sent by the endocrine organs. Hormones are transported primarily via the bloodstream throughout the body, where they bind to receptors on target cells, inducing a characteristic response. Some of the glands in the endocrine system include the pituitary, thyroid, parathyroid, adrenal, and pineal glands. See Figure 9.1 for an illustration of the endocrine system.[footnote]\"1801 The Endocrine System.jpg<\/a>\" by OpenStax<\/a> is licensed under CC BY 4.0<\/a> Access for free at https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/17-1-an-overview-of-the-endocrine-system<\/a>[\/footnote]<\/sup>\u00a0 Some of these glands have both endocrine and nonendocrine functions. For example, the pancreas contains cells that function in digestion, as well as cells that secrete the hormones insulin and glucagon, which regulate blood glucose levels.[footnote]This work is a derivative of Anatomy and Physiology<\/a> by OpenStax<\/a> licensed under CC BY 4.0<\/a>. Access for free at https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/1-introduction<\/a>[\/footnote]<\/sup>\n\n[caption id=\"\" align=\"aligncenter\" width=\"752\"]\"Illustration Figure 9.1 Overview of the Endocrine System[\/caption]\n\nThis module will focus on medications that affect three major endocrine glands and their hormones: the adrenal glands, the pancreas, and the thyroid. See Table 9.1 for a list of hormones associated with each of these glands and their effects.<\/span>[footnote]This work is a derivative of\u00a0Anatomy and Physiology<\/a>\u00a0by\u00a0OpenStax<\/a>\u00a0licensed under\u00a0CC BY 4.0<\/a>. Access for free at\u00a0https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/1-introduction<\/a>[\/footnote]<\/span><\/sup>\n\nTable 9.1. Hormones Associated with Adrenal Gland, Pancreas, and Thyroid and Their Effects\n\n\n\n\n\n\n\n\n\n\n
Endocrine gland<\/th>\nHormone<\/th>\nEffect<\/th>\n<\/tr>\n
Adrenal (cortex)<\/th>\nAldosterone<\/td>\nIncreases blood Na+ levels<\/td>\n<\/tr>\n
Adrenal (cortex)<\/th>\nCortisol<\/td>\nIncreases blood sugar levels<\/td>\n<\/tr>\n
Adrenal (medulla)<\/th>\nEpinephrine and Norepinephrine<\/td>\nStimulates fight-or-flight response<\/td>\n<\/tr>\n
Pancreas<\/th>\nInsulin<\/td>\nReduces blood glucose levels<\/td>\n<\/tr>\n
Pancreas<\/th>\nGlucagon<\/td>\nIncreases blood glucose levels<\/td>\n<\/tr>\n
Thyroid<\/th>\nThyroxine (T4), triiodothyronine (T3)<\/td>\nStimulates basal metabolic rate<\/td>\n<\/tr>\n
Thyroid<\/th>\nCalcitonin<\/td>\nReduces blood Ca+ levels<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/a>Regulation of Hormone Secretion<\/h2>\nTo prevent abnormal hormone levels and a potential disease state, hormone levels must be tightly controlled. Feedback loops govern the initiation and maintenance of hormone secretion in response to various stimuli.\n\nThe most common method of hormone regulation is the [pb_glossary id=\"1718\"]negative feedback loop.[\/pb_glossary]<\/strong> Negative feedback is characterized by the inhibition of further secretion of a hormone in response to adequate levels of that hormone. This allows blood levels of the hormone to be regulated within a narrow range. An example of a negative feedback loop is the release of glucocorticoid hormones from the adrenal glands, as directed by the hypothalamus and pituitary gland. As glucocorticoid concentrations in the blood rise, the hypothalamus and pituitary gland reduce their signaling to the adrenal glands to prevent additional glucocorticoid secretion.[footnote]This work is a derivative of Anatomy and Physiology<\/a> by OpenStax<\/a> licensed under CC BY 4.0<\/a>. Access for free at https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/1-introduction<\/a>[\/footnote]<\/sup> See Figure 9.2 for an illustration of a negative feedback loop.[footnote]\"1805 Negative Feedback Loop.jpg<\/a>\" by OpenStax<\/a> is licensed under CC BY 4.0<\/a> Access for free at https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/17-2-hormones<\/a>[\/footnote]<\/sup>\n\n[caption id=\"\" align=\"aligncenter\" width=\"607\"]\"Illustration Figure 9.2 Negative Feedback Loop[\/caption]\n

<\/a>Endocrine Gland Stimuli<\/h2>\nEndocrine glands can be stimulated by humoral stimuli, by stimulation of another hormone, or by neural stimuli. [pb_glossary id=\"1719\"]Humoral stimuli [\/pb_glossary]<\/strong> are changes in blood levels of non-hormone chemicals that cause the release or inhibition of a hormone to maintain homeostasis. For example, osmoreceptors in the hypothalamus detect changes in [pb_glossary id=\"1720\"]blood osmolarity[\/pb_glossary]<\/strong> (the concentration of solutes in the blood plasma). If blood osmolarity is too high, meaning that the blood is not dilute enough, osmoreceptors signal the hypothalamus to release ADH (antidiuretic hormone). ADH causes the kidneys to reabsorb more water and reduce the volume of urine produced. This reabsorption causes a reduction of the osmolarity of the blood by diluting the blood to the appropriate level. Another example of humoral stimuli is the regulation of blood glucose. High blood glucose levels cause the release of insulin from the pancreas, which increases glucose uptake by cells and liver storage of glucose as glycogen.\n\nAn endocrine gland may also secrete a hormone in response to the presence of another hormone produced by a different endocrine gland. For example, the thyroid gland secretes T4 into the bloodstream when triggered by thyroid-stimulating hormone (TSH) that is released from the anterior pituitary gland.\n\nIn addition to these chemical signals, hormones can also be released in response to [pb_glossary id=\"1721\"]neural stimuli[\/pb_glossary]<\/strong>. An example of neural stimuli is the activation of the fight-or-flight response by the sympathetic nervous system. When an individual perceives danger, sympathetic neurons signal the adrenal glands to secrete norepinephrine and epinephrine. The two hormones dilate blood vessels, increase the heart and respiratory rate, and suppress the digestive and immune systems. These responses boost the body's transport of oxygen to the brain and muscles, thereby improving the body's ability to fight or flee.[footnote]This work is a derivative of Anatomy and Physiology<\/a> by OpenStax<\/a> licensed under CC BY 4.0<\/a>. Access for free at https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/1-introduction<\/a>[\/footnote]<\/sup>\n

<\/a>The Hypothalamus\u2013Pituitary Complex<\/h2>\nThe [pb_glossary id=\"1722\"]hypothalamus\u2013pituitary complex[\/pb_glossary]<\/strong> can be thought of as the \"command center\" of the endocrine system. This complex secretes several hormones that directly produce responses in target tissues, as well as hormones that regulate the synthesis and secretion of hormones of other glands. In addition, the hypothalamus\u2013pituitary complex coordinates the messages of the endocrine and nervous systems. In many cases, a stimulus received by the nervous system must pass through the hypothalamus\u2013pituitary complex to be translated into hormones that can initiate a response. See Figure 9.3 for an illustration of the hypothalamus\u2013pituitary complex.[footnote]\"1806 The Hypothalamus-Pituitary Complex.jpg<\/a>\" by OpenStax<\/a> is licensed under CC BY 4.0<\/a> Access for free at https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/17-3-the-pituitary-gland-and-hypothalamus<\/a>[\/footnote] The hypothalamus connects to the pituitary gland by the stalk-like infundibulum. The pituitary gland consists of an anterior and posterior lobe, with each lobe secreting different hormones in response to signals from the hypothalamus.\n\n[caption id=\"\" align=\"aligncenter\" width=\"604\"]\"Illustration Figure 9.3 Illustration of the Hypothalamus\u2013Pituitary Complex[\/caption]\n

<\/a>Posterior Pituitary<\/h3>\nThe posterior pituitary gland does not produce hormones, but stores and secretes two hormones produced by the hypothalamus: oxytocin and antidiuretic hormone (ADH).\n

<\/a>Antidiuretic Hormone (ADH)<\/h4>\nBlood osmolarity, the concentration of sodium ions and other solutes, is constantly monitored by [pb_glossary id=\"1723\"]osmoreceptors[\/pb_glossary] <\/strong>in the hypothalamus. Blood osmolarity may change in response to the consumption of certain foods and fluids, as well as in response to disease, injury, medications, or other factors. In response to high blood osmolarity, which can occur during dehydration or following a very salty meal, the osmoreceptors signal the posterior pituitary to release antidiuretic hormone (ADH). Its effect is to cause increased water reabsorption by the kidneys. As more water is reabsorbed by the kidneys, a greater amount of water is returned to the blood, thus causing a decrease in blood osmolarity. The release of ADH is controlled by a negative feedback loop. As blood osmolarity decreases, the hypothalamic osmoreceptors sense the change and prompt a corresponding decrease in the secretion of ADH. As a result, less water is reabsorbed by the kidneys.\n\nDrugs can also affect the secretion of ADH or imitate its effects. For example, alcohol consumption inhibits the release of ADH, resulting in increased urine production that can eventually lead to dehydration and a hangover. Vasopressin is a synthetic ADH medication used to treat very low blood pressure. It is called vasopressin because in very high concentrations it also causes constriction of blood vessels in addition to the retention of water. Vasopressin is also used to treat a disease called [pb_glossary id=\"1724\"]diabetes insipidus (DI)[\/pb_glossary] <\/strong>that causes dehydration due to an underproduction of ADH. [footnote]This work is a derivative of Anatomy and Physiology<\/a> by OpenStax<\/a> licensed under CC BY 4.0<\/a>. Access for free at https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/1-introduction<\/a>[\/footnote]<\/sup>\n

<\/a>Anterior Pituitary<\/h3>\nIn contrast to the posterior pituitary, the anterior pituitary does manufacture hormones. However, the secretion of hormones from the anterior pituitary is regulated by two classes of hormones secreted by the hypothalamus called releasing hormones. Releasing hormones then stimulate the secretion of hormones from the anterior pituitary (see Figure 9.4[footnote]\"1808 The Anterior Pituitary Complex.jpg<\/a>\" by OpenStax<\/a> is licensed under CC BY 4.0<\/a> Access for free at https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/17-3-the-pituitary-gland-and-hypothalamus<\/a>[\/footnote]<\/sup>). The anterior pituitary produces seven hormones. These are the growth hormone (GH), thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), beta endorphin, and prolactin. Of the hormones of the anterior pituitary, TSH, ACTH, FSH, and LH are collectively referred to as [pb_glossary id=\"1725\"]tropic hormones<\/strong> [\/pb_glossary] (trope- = \"turning\") because they turn on or off the function of other endocrine glands. This module will focus on the effects of TSH and ACTH.\n\n[caption id=\"\" align=\"aligncenter\" width=\"904\"]\"Illustration Figure 9.4 The hypothalamus releases hormones to regulate the release of hormones from the anterior pituitary[\/caption]\n

<\/a>Thyroid-Stimulating Hormone (TSH)<\/h4>\nThe activity of the thyroid gland is regulated by the thyroid-stimulating hormone (TSH). TSH is released from the anterior pituitary in response to the thyrotropin-releasing hormone (TRH) from the hypothalamus and triggers the secretion of thyroid hormones by the thyroid gland. In a classic negative feedback loop, elevated levels of thyroid hormones in the bloodstream then trigger a drop in production of TRH and subsequently, the production of TSH. TSH is further discussed in the \"Thyroid\" submodule.\n

<\/a>Adrenocorticotropic Hormone (ACTH)<\/h4>\nThe adrenocorticotropic hormone (ACTH) is released from the anterior pituitary in response to the corticotropin-releasing hormone (CRH) from the hypothalamus. ACTH then stimulates the adrenal cortex to secrete corticosteroid hormones such as cortisol. A variety of stressors can also influence the release of ACTH, and the role of ACTH in the stress response is discussed under the \"Adrenal\" submodule.[footnote]This work is a derivative of Anatomy and Physiology<\/a> by OpenStax<\/a> licensed under CC BY 4.0<\/a>. Access for free at https:\/\/openstax.org\/books\/anatomy-and-physiology\/pages\/1-introduction<\/a>[\/footnote]<\/sup>\n
<\/div>\n
\n

\u00a0Interactive Activity<\/h3>\n[h5p id=\"27\"]\n\n<\/div>\n<\/div>","rendered":"
\n

You may never have thought of it this way, but when you send a text message to two friends to meet you at a restaurant at six, you’re sending digital signals that you hope will affect their behavior\u2014even though they are some distance away. Similarly, certain cells send chemical signals to other cells in the body that influence their behavior. This long-distance intercellular communication, coordination, and control are critical for homeostasis, and it is the fundamental function of the endocrine system.<\/p>\n

Whereas the nervous system uses neurotransmitters to communicate, the endocrine system uses hormones<\/strong> for chemical signaling. These hormone signals are sent by the endocrine organs. Hormones are transported primarily via the bloodstream throughout the body, where they bind to receptors on target cells, inducing a characteristic response. Some of the glands in the endocrine system include the pituitary, thyroid, parathyroid, adrenal, and pineal glands. See Figure 9.1 for an illustration of the endocrine system.[1]<\/sup><\/a><\/sup>\u00a0 Some of these glands have both endocrine and nonendocrine functions. For example, the pancreas contains cells that function in digestion, as well as cells that secrete the hormones insulin and glucagon, which regulate blood glucose levels.[2]<\/sup><\/a><\/sup><\/p>\n

\"Illustration
Figure 9.1 Overview of the Endocrine System<\/figcaption><\/figure>\n

This module will focus on medications that affect three major endocrine glands and their hormones: the adrenal glands, the pancreas, and the thyroid. See Table 9.1 for a list of hormones associated with each of these glands and their effects.<\/span>[3]<\/sup><\/a><\/span><\/sup><\/p>\n

Table 9.1. Hormones Associated with Adrenal Gland, Pancreas, and Thyroid and Their Effects<\/p>\n\n\n\n\n\n\n\n\n\n\n
Endocrine gland<\/th>\nHormone<\/th>\nEffect<\/th>\n<\/tr>\n
Adrenal (cortex)<\/th>\nAldosterone<\/td>\nIncreases blood Na+ levels<\/td>\n<\/tr>\n
Adrenal (cortex)<\/th>\nCortisol<\/td>\nIncreases blood sugar levels<\/td>\n<\/tr>\n
Adrenal (medulla)<\/th>\nEpinephrine and Norepinephrine<\/td>\nStimulates fight-or-flight response<\/td>\n<\/tr>\n
Pancreas<\/th>\nInsulin<\/td>\nReduces blood glucose levels<\/td>\n<\/tr>\n
Pancreas<\/th>\nGlucagon<\/td>\nIncreases blood glucose levels<\/td>\n<\/tr>\n
Thyroid<\/th>\nThyroxine (T4), triiodothyronine (T3)<\/td>\nStimulates basal metabolic rate<\/td>\n<\/tr>\n
Thyroid<\/th>\nCalcitonin<\/td>\nReduces blood Ca+ levels<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/a>Regulation of Hormone Secretion<\/h2>\n

To prevent abnormal hormone levels and a potential disease state, hormone levels must be tightly controlled. Feedback loops govern the initiation and maintenance of hormone secretion in response to various stimuli.<\/p>\n

The most common method of hormone regulation is the negative feedback loop.<\/strong> Negative feedback is characterized by the inhibition of further secretion of a hormone in response to adequate levels of that hormone. This allows blood levels of the hormone to be regulated within a narrow range. An example of a negative feedback loop is the release of glucocorticoid hormones from the adrenal glands, as directed by the hypothalamus and pituitary gland. As glucocorticoid concentrations in the blood rise, the hypothalamus and pituitary gland reduce their signaling to the adrenal glands to prevent additional glucocorticoid secretion.[4]<\/sup><\/a><\/sup> See Figure 9.2 for an illustration of a negative feedback loop.[5]<\/sup><\/a><\/sup><\/p>\n

\"Illustration
Figure 9.2 Negative Feedback Loop<\/figcaption><\/figure>\n

<\/a>Endocrine Gland Stimuli<\/h2>\n

Endocrine glands can be stimulated by humoral stimuli, by stimulation of another hormone, or by neural stimuli. Humoral stimuli <\/strong> are changes in blood levels of non-hormone chemicals that cause the release or inhibition of a hormone to maintain homeostasis. For example, osmoreceptors in the hypothalamus detect changes in blood osmolarity<\/strong> (the concentration of solutes in the blood plasma). If blood osmolarity is too high, meaning that the blood is not dilute enough, osmoreceptors signal the hypothalamus to release ADH (antidiuretic hormone). ADH causes the kidneys to reabsorb more water and reduce the volume of urine produced. This reabsorption causes a reduction of the osmolarity of the blood by diluting the blood to the appropriate level. Another example of humoral stimuli is the regulation of blood glucose. High blood glucose levels cause the release of insulin from the pancreas, which increases glucose uptake by cells and liver storage of glucose as glycogen.<\/p>\n

An endocrine gland may also secrete a hormone in response to the presence of another hormone produced by a different endocrine gland. For example, the thyroid gland secretes T4 into the bloodstream when triggered by thyroid-stimulating hormone (TSH) that is released from the anterior pituitary gland.<\/p>\n

In addition to these chemical signals, hormones can also be released in response to neural stimuli<\/strong>. An example of neural stimuli is the activation of the fight-or-flight response by the sympathetic nervous system. When an individual perceives danger, sympathetic neurons signal the adrenal glands to secrete norepinephrine and epinephrine. The two hormones dilate blood vessels, increase the heart and respiratory rate, and suppress the digestive and immune systems. These responses boost the body’s transport of oxygen to the brain and muscles, thereby improving the body’s ability to fight or flee.[6]<\/sup><\/a><\/sup><\/p>\n

<\/a>The Hypothalamus\u2013Pituitary Complex<\/h2>\n

The hypothalamus\u2013pituitary complex<\/strong> can be thought of as the “command center” of the endocrine system. This complex secretes several hormones that directly produce responses in target tissues, as well as hormones that regulate the synthesis and secretion of hormones of other glands. In addition, the hypothalamus\u2013pituitary complex coordinates the messages of the endocrine and nervous systems. In many cases, a stimulus received by the nervous system must pass through the hypothalamus\u2013pituitary complex to be translated into hormones that can initiate a response. See Figure 9.3 for an illustration of the hypothalamus\u2013pituitary complex.[7]<\/sup><\/a> The hypothalamus connects to the pituitary gland by the stalk-like infundibulum. The pituitary gland consists of an anterior and posterior lobe, with each lobe secreting different hormones in response to signals from the hypothalamus.<\/p>\n

\"Illustration
Figure 9.3 Illustration of the Hypothalamus\u2013Pituitary Complex<\/figcaption><\/figure>\n

<\/a>Posterior Pituitary<\/h3>\n

The posterior pituitary gland does not produce hormones, but stores and secretes two hormones produced by the hypothalamus: oxytocin and antidiuretic hormone (ADH).<\/p>\n

<\/a>Antidiuretic Hormone (ADH)<\/h4>\n

Blood osmolarity, the concentration of sodium ions and other solutes, is constantly monitored by osmoreceptors <\/strong>in the hypothalamus. Blood osmolarity may change in response to the consumption of certain foods and fluids, as well as in response to disease, injury, medications, or other factors. In response to high blood osmolarity, which can occur during dehydration or following a very salty meal, the osmoreceptors signal the posterior pituitary to release antidiuretic hormone (ADH). Its effect is to cause increased water reabsorption by the kidneys. As more water is reabsorbed by the kidneys, a greater amount of water is returned to the blood, thus causing a decrease in blood osmolarity. The release of ADH is controlled by a negative feedback loop. As blood osmolarity decreases, the hypothalamic osmoreceptors sense the change and prompt a corresponding decrease in the secretion of ADH. As a result, less water is reabsorbed by the kidneys.<\/p>\n

Drugs can also affect the secretion of ADH or imitate its effects. For example, alcohol consumption inhibits the release of ADH, resulting in increased urine production that can eventually lead to dehydration and a hangover. Vasopressin is a synthetic ADH medication used to treat very low blood pressure. It is called vasopressin because in very high concentrations it also causes constriction of blood vessels in addition to the retention of water. Vasopressin is also used to treat a disease called diabetes insipidus (DI) <\/strong>that causes dehydration due to an underproduction of ADH. [8]<\/sup><\/a><\/sup><\/p>\n

<\/a>Anterior Pituitary<\/h3>\n

In contrast to the posterior pituitary, the anterior pituitary does manufacture hormones. However, the secretion of hormones from the anterior pituitary is regulated by two classes of hormones secreted by the hypothalamus called releasing hormones. Releasing hormones then stimulate the secretion of hormones from the anterior pituitary (see Figure 9.4[9]<\/sup><\/a><\/sup>). The anterior pituitary produces seven hormones. These are the growth hormone (GH), thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), beta endorphin, and prolactin. Of the hormones of the anterior pituitary, TSH, ACTH, FSH, and LH are collectively referred to as tropic hormones<\/strong> (trope- = “turning”) because they turn on or off the function of other endocrine glands. This module will focus on the effects of TSH and ACTH.<\/p>\n

\"Illustration
Figure 9.4 The hypothalamus releases hormones to regulate the release of hormones from the anterior pituitary<\/figcaption><\/figure>\n

<\/a>Thyroid-Stimulating Hormone (TSH)<\/h4>\n

The activity of the thyroid gland is regulated by the thyroid-stimulating hormone (TSH). TSH is released from the anterior pituitary in response to the thyrotropin-releasing hormone (TRH) from the hypothalamus and triggers the secretion of thyroid hormones by the thyroid gland. In a classic negative feedback loop, elevated levels of thyroid hormones in the bloodstream then trigger a drop in production of TRH and subsequently, the production of TSH. TSH is further discussed in the “Thyroid” submodule.<\/p>\n

<\/a>Adrenocorticotropic Hormone (ACTH)<\/h4>\n

The adrenocorticotropic hormone (ACTH) is released from the anterior pituitary in response to the corticotropin-releasing hormone (CRH) from the hypothalamus. ACTH then stimulates the adrenal cortex to secrete corticosteroid hormones such as cortisol. A variety of stressors can also influence the release of ACTH, and the role of ACTH in the stress response is discussed under the “Adrenal” submodule.[10]<\/sup><\/a><\/sup><\/p>\n

<\/div>\n
\n

\u00a0Interactive Activity<\/h3>\n
\n